Transforming growth factor-beta increases the expression of vascular smooth muscle cell Markers in human multi-lineage progenitor cells | Zendy

Hui Yang | Zendy; Lidong Zhang | Zendy; Sarah M. Weakley | Zendy; Peter H. Lin | Zendy; Qizhi Yao | Zendy; Changyi Chen | Zendy

Open Access

Transforming growth factor-beta increases the expression of vascular smooth muscle cell Markers in human multi-lineage progenitor cells

Author(s) -

Hui Yang,

Lidong Zhang,

Sarah M. Weakley,

Peter H. Lin,

Qizhi Yao,

Changyi Chen

Publication year - 2011

Publication title -

medical science monitor

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.636

H-Index - 85

eISSN - 1643-3750

pISSN - 1234-1010

DOI - 10.12659/msm.881439

Subject(s) - cd146 , calponin , progenitor cell , biology , lineage markers , cd34 , mesenchymal stem cell , microbiology and biotechnology , stem cell , cellular differentiation , stem cell marker , cd44 , endoglin , endothelial stem cell , transforming growth factor beta , transforming growth factor , cell , actin , in vitro , genetics , gene

Vascular smooth muscle cell (SMC) differentiation is an essential component of vascular repair and tissue engineering. However, currently used cell models for the study of SMC differentiation have several limitations. Multi-lineage progenitor cells (MLPCs) originate from human umbilical cord blood and are cloned from a single cell. The object of this study was to investigate whether MLPCs could differentiate into SMCs in vitro with induction by transforming growth factor beta1 (TGF-beta1).

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