Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats | Zendy

Ivan Matia | Zendy; Peter Fellmer | Zendy; Katrin Splith | Zendy; Martin Varga | Zendy; Miloš Adamec | Zendy; Ines Kämmerer | Zendy; Linda Feldbrügge | Zendy; Felix Krenzien | Zendy; HansMichael Hau | Zendy; Georgi Atanasov | Zendy; Moritz Schmelzle | Zendy; Sven Jonas | Zendy

Open Access

Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats

Author(s) -

Ivan Matia,

Peter Fellmer,

Katrin Splith,

Martin Varga,

Miloš Adamec,

Ines Kämmerer,

Linda Feldbrügge,

Felix Krenzien,

HansMichael Hau,

Georgi Atanasov,

Moritz Schmelzle,

Sven Jonas

Publication year - 2014

Publication title -

annals of transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.494

H-Index - 38

eISSN - 2329-0358

pISSN - 1425-9524

DOI - 10.12659/aot.889870

Subject(s) - tacrolimus , medicine , immunosuppression , antibody , transplantation , major histocompatibility complex , mhc class i , immunology , mhc class ii , andrology , immune system

Arterial allografts are used as vascular conduits in the treatment of prosthetic graft infection. Immunosuppression decreases their rupture risk rate. However, immunosuppression can be unprofitable in florid infection. Previously, we confirmed inhibition of cell-mediated destruction of rat aortic grafts by delayed use of tacrolimus. In this work, we studied the influence of this protocol on the antibody-mediated rejection.

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