Open AccessGlobal analysis of mRNA splicing
Author(s) -
Michael J. Moore,
Pamela A. Silver
Publication year - 2007
Publication title -
rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.037
H-Index - 171
eISSN - 1469-9001
pISSN - 1355-8382
DOI - 10.1261/rna.868008
Subject(s) - biology , rna splicing , computational biology , alternative splicing , messenger rna , precursor mrna , genetics , gene , rna
Alternative mRNA splicing is a rich source of transcript diversity in eukaryotic cells with broad roles in development and disease. Systems-wide experimental methods have started to define how global splicing regulation shapes complex biological properties and pathways. Here, we review these approaches, describe recent insights they have yielded, and discuss avenues of future investigation.
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