Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions | Zendy

Kexiong Zhang | Zendy; Qiaoqiao Wang | Zendy; Yanhua Xie | Zendy; Gil Mor | Zendy; Emanuela Sega | Zendy; Philip S. Low | Zendy; Yingqun Huang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions

Author(s) -

Kexiong Zhang,

Qiaoqiao Wang,

Yanhua Xie,

Gil Mor,

Emanuela Sega,

Philip S. Low,

Yingqun Huang

Publication year - 2008

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.739308

Subject(s) - small interfering rna , nucleic acid , biology , gene silencing , microbiology and biotechnology , trans acting sirna , receptor , rna , biochemistry , gene

We report a new strategy for cell-type-specific delivery of functional siRNAs into cells. The method involves the noncovalent attachment of siRNAs to ligand-conjugated oligodeoxynucleotides via nucleic acid base-paired interactions. The resulting complexes can be directly applied to cells, leading to specific cellular uptake and gene silencing. The method is simple, economical, and can be easily adapted for other cell surface receptors. Here we show the application of this method for the delivery of siRNAs to folate receptor-expressing cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research