RNA editing of a miRNA precursor: FIGURE 1. | Zendy

D Luciano | Zendy; Henry Mirsky | Zendy; Nicholas Vendetti | Zendy; Stefan Maas | Zendy

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RNA editing of a miRNA precursor: FIGURE 1.

Author(s) -

D Luciano,

Henry Mirsky,

Nicholas Vendetti,

Stefan Maas

Publication year - 2004

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.7350304

Subject(s) - biology , rna editing , rna , microrna , non coding rna , biogenesis , gene , computational biology , guide rna , genetics , rna binding protein , gene expression , regulation of gene expression , rna silencing , genome editing , rna interference , crispr

Micro RNAs comprise a large family of small, functional RNAs with important roles in the regulation of protein coding genes in animals and plants. Here we show that human and mouse miRNA22 precursor molecules are subject to posttranscriptional modification by A-to-I RNA editing in vivo. The observed editing events are predicted to have significant implications for the biogenesis and function of miRNA22 and might point toward a more general role for RNA editing in the regulation of miRNA gene expression.

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