miR-200b mediates post-transcriptional repression of ZFHX1B | Zendy

Nanna R. Christoffersen | Zendy; Asli Silahtaroglu | Zendy; Ulf Andersson Ørom | Zendy; Sakari Kauppinen | Zendy; Anders H. Lund | Zendy

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miR-200b mediates post-transcriptional repression of ZFHX1B

Author(s) -

Nanna R. Christoffersen,

Asli Silahtaroglu,

Ulf Andersson Ørom,

Sakari Kauppinen,

Anders H. Lund

Publication year - 2007

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.586807

Subject(s) - psychological repression , biology , repressor , microrna , three prime untranslated region , endogeny , microbiology and biotechnology , untranslated region , transcriptional regulation , regulation of gene expression , messenger rna , transition (genetics) , genetics , gene expression , gene , endocrinology

MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their cognate mRNA targets. ZFHX1B is a transcriptional repressor involved in the TGFβ signaling pathway and in processes of epithelial to mesenchymal transition via regulation of E-cadherin. We show that Zfhx1b and miR-200b are regionally coexpressed in the adult mouse brain and that miR-200b represses the expression of Zfhx1b via multiple sequence elements present in the 3′-untranslated region. Overexpression of miR-200b leads to repression of endogenous ZFHX1B, and inhibition of miR-200b relieves the repression of ZFHX1B. In accordance with these findings, miR-200b regulates the activity of the E-cadherin promoter.

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