English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Using mutants ( tgt, mnmA ( asuE ,  trmU ) , mnmE ( trmE ) , miaA, miaB, miaE, truA ( hisT ) , truB ) of either  Escherichia coli  or  Salmonella enterica  serovar Typhimurium and the  trm5  mutant of  Saccharomyces cerevisiae , we have analyzed the influence by the modified nucleosides Q34, mnm 5 s 2 U34, ms 2 io 6 A37, Ψ39, Ψ55, m 1 G37, and yW37 on −1 frameshifts errors at various heptameric sequences, at which at least one codon is decoded by tRNAs having these modified nucleosides. The frequency of −1 frameshifting was the same in congenic strains only differing in the allelic state of the various tRNA modification genes. In fact, in one case (deficiency of mnm 5 s 2 U34), we observed a  reduced  ability of the undermodified tRNA to make a −1 frameshift error. These results are in sharp contrast to earlier observations that tRNA modification prevents +1 frameshifting suggesting that the mechanisms by which −1 and +1 frameshift errors occur are different. Possible mechanisms explaining these results are discussed.

Transfer RNA modifications that alter +1 frameshifting in general fail to affect −1 frameshifting