A family of poly(U) polymerases | Zendy

Jae Kwak | Zendy; Marvin Wickens | Zendy

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A family of poly(U) polymerases

Author(s) -

Jae Kwak,

Marvin Wickens

Publication year - 2007

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.514007

Subject(s) - biology , schizosaccharomyces pombe , polymerase , caenorhabditis elegans , rna , enzyme , biochemistry , arabidopsis , schizosaccharomyces , genetics , yeast , mutant , gene , saccharomyces cerevisiae

The GLD-2 family of poly(A) polymerases add successive AMP monomers to the 3' end of specific RNAs, forming a poly(A) tail. Here, we identify a new group of GLD-2-related nucleotidyl transferases from Arabidopsis, Schizosaccharomyces pombe, Caenorhabditis elegans, and humans. Like GLD-2, these enzymes are template independent and add nucleotides to the 3' end of an RNA substrate. However, these new enzymes, which we refer to as poly(U) polymerases, add poly(U) rather than poly(A) to their RNA substrates.

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