The imprinted H19 noncoding RNA is a primary microRNA precursor | Zendy

Xuezhong Cai | Zendy; Bryan R. Cullen | Zendy

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The imprinted H19 noncoding RNA is a primary microRNA precursor

Author(s) -

Xuezhong Cai,

Bryan R. Cullen

Publication year - 2007

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.351707

Subject(s) - biology , microrna , non coding rna , long non coding rna , rna , downregulation and upregulation , genomic imprinting , microbiology and biotechnology , transfection , plasmid , function (biology) , genetics , gene expression , gene , dna methylation

Although H19 was the first imprinted noncoding transcript to be identified, the function of this conserved RNA has remained unclear. Here, we identify a 23-nucleotide microRNA derived from H19 that is endogenously expressed in human keratinocytes and neonatal mice and overexpressed in cells transfected with human or mouse H19 expression plasmids. These data demonstrate that H19 can function as a primary microRNA precursor and suggest that H19 expression results in the post-transcriptional downregulation of specific mRNAs during vertebrate development.

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