Stm1 modulates translation after 80S formation inSaccharomyces cerevisiae | Zendy

Vidya Balagopal | Zendy; Roy Parker | Zendy

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Stm1 modulates translation after 80S formation inSaccharomyces cerevisiae

Author(s) -

Vidya Balagopal,

Roy Parker

Publication year - 2011

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.2677311

Subject(s) - biology , translation (biology) , saccharomyces cerevisiae , ribosome , messenger rna , protein biosynthesis , microbiology and biotechnology , eukaryotic translation , eif4e , translational regulation , genetics , gene , rna

The control of translation is a critical aspect of gene regulation. It is often inversely related to mRNA degradation and is typically controlled during initiation. The Stm1 protein in Saccharomyces cerevisiae has been shown to interact with ribosomes, affect the interaction of eEF3 with ribosomes, and promote the decapping of a subclass of mRNAs. We demonstrate that in vitro Stm1 inhibits translation after formation of an 80S complex. This suggests that Stm1 modulates translation and mRNA decapping by controlling translation elongation.

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