KISS: The kinetoplastid RNA editing sequence search tool | Zendy

Torsten Ochsenreiter | Zendy; Michael J. Cipriano | Zendy; Stephen L. Hajduk | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

KISS: The kinetoplastid RNA editing sequence search tool

Author(s) -

Torsten Ochsenreiter,

Michael J. Cipriano,

Stephen L. Hajduk

Publication year - 2006

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.232907

Subject(s) - rna editing , biology , minicircle , guide rna , kiss (tnc) , trypanosoma brucei , genetics , rna , kinetoplast , computational biology , gene , crispr , genome editing , dna , computer science , computer network

Kinetoplastid mitochondrial mRNA editing is a post-transcriptional process of uridine insertion and deletion. Editing is mediated by small RNA molecules termed guide RNAs (gRNAs). Most gRNAs are encoded by numerous small circular DNA minicircles, while the protein coding mitochondrial genes are encoded on a separate, larger genome called the maxicircle. In order to provide a workbench for the analysis of RNA editing in kinetoplastids and a well-annotated set of guide RNAs for Trypanosoma brucei, we generated the kinetoplastid RNA editing sequence search tool (KISS) (http://gmod.mbl.edu/kiss/). KISS is a pipeline and database that uses BLAST comparisons and minicircle sequence motifs to annotate potential gRNAs and cognate mRNA editing sequence. KISS 1.0 contains all previously known minicircle and maxicircle data from Trypanosoma brucei plus >400 new minicircle sequences. Using an online format, KISS 1.0 allows the mapping and visualization of all known T. brucei gRNAs to minicircle genes and to potential mRNA substrates for RNA editing.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research