Sulfolobus solfataricus translation initiation factor 1 stimulates translation initiation complex formation | Zendy

David Hasenöhrl | Zendy; Dario Benelli | Zendy; ALESSANDRA BARBAZZA | Zendy; Paola Londei | Zendy; Udo Bläsi | Zendy

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Sulfolobus solfataricus translation initiation factor 1 stimulates translation initiation complex formation

Author(s) -

David Hasenöhrl,

Dario Benelli,

ALESSANDRA BARBAZZA,

Paola Londei,

Udo Bläsi

Publication year - 2006

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.2289306

Subject(s) - sulfolobus solfataricus , biology , eukaryotic translation , eukaryotic initiation factor , initiation factor , translation (biology) , eif4a1 , eif2 , start codon , five prime untranslated region , ribosome , eukaryotic translation initiation factor 4 gamma , messenger rna , eif4e , genetics , microbiology and biotechnology , rna , gene , archaea

The eukaryotic translation initiation factor 1 binds to the ribosome during translation initiation. It is instrumental for initiator-tRNA and mRNA binding, and has a function in selection of the authentic start codon. Here, we show that the archaeal homolog aIF1 has analogous functions. The aIF1 protein of the archaeon Sulfolobus solfataricus is bound to the small ribosomal subunit during translation initiation and accelerates binding of initiator-tRNA and mRNA to the ribosome. Accordingly, aIF1 stimulated translation of an mRNA in a S. solfataricus in vitro translation system. Moreover, this study suggested that the C terminus of the factor is of relevance for its function.

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