The effect of a single, temperature-sensitive mutation on global gene expression in Escherichia coli | Zendy

Yong Li | Zendy; Kyle Brubaker Cole | Zendy; Sidney Altman | Zendy

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The effect of a single, temperature-sensitive mutation on global gene expression in Escherichia coli

Author(s) -

Yong Li,

Kyle Brubaker Cole,

Sidney Altman

Publication year - 2003

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.2198203

Subject(s) - biology , dna microarray , gene , genetics , escherichia coli , rnase p , gene cluster , gene expression , intergenic region , microbiology and biotechnology , rna , genome

High-density DNA microarrays have been used to explore the genomic profiling of gene expression of a defective Escherichia coli strain with a temperature-sensitive mutation in the protein component of RNase P. A novel gene cluster was discovered in which two of the genes are known substrates of RNase P. The expression pattern of essential genes and gene discovery from intergenic regions, for which other new transcripts are found, are also discussed.

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