Dicer independent small RNAs associate with telomeric heterochromatin | Zendy

Fang Cao | Zendy; Xiangzhi Li | Zendy; Samantha Hiew | Zendy; Hugh J.M. Brady | Zendy; Yifan Liu | Zendy; Yali Dou | Zendy

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Dicer independent small RNAs associate with telomeric heterochromatin

Author(s) -

Fang Cao,

Xiangzhi Li,

Samantha Hiew,

Hugh J.M. Brady,

Yifan Liu,

Yali Dou

Publication year - 2009

Publication title -

rna

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.037

H-Index - 171

eISSN - 1469-9001

pISSN - 1355-8382

DOI - 10.1261/rna.1423309

Subject(s) - biology , dicer , heterochromatin , genetics , small nucleolar rna , argonaute , computational biology , microrna , non coding rna , rna , rna interference , dna , chromatin , gene

Small RNAs play important roles in the establishment and maintenance of heterochromatin structures. We show the presence of telomere specific small RNAs (tel-sRNAs) in mouse embryonic stem cells that are ∼24 nucleotides in length, Dicer-independent, and 2′- O -methylated at the 3′ terminus. The tel-sRNAs are asymmetric with specificity toward telomere G-rich strand, and evolutionarily conserved from protozoan to mammalian cells. Furthermore, tel-sRNAs are up-regulated in cells that carry null mutation of H3K4 methyltransferase MLL ( Mll (−/−) ) and down-regulated in cells that carry null mutations of histone H3K9 methyltransferase SUV39H ( Suv39h1/h2 (−/−) ), suggesting that they are subject to epigenetic regulation. These results support that tel-sRNAs are heterochromatin associated pi-like small RNAs.

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