Open AccessMiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas
Author(s) -
ZhuMei Shi,
Xie-feng Wang,
Xu Qian,
Tao Tao,
Lin Wang,
Qiu-dan Chen,
Xi-rui Wang,
Lei Cao,
Ying-yi Wang,
Jun-xia Zhang,
Tao Jiang,
Chunsheng Kang,
BingHua Jiang,
Ning Liu,
Yong-ping You
Publication year - 2013
Publication title -
rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.037
H-Index - 171
eISSN - 1469-9001
pISSN - 1355-8382
DOI - 10.1261/rna.035972.112
Subject(s) - biology , microrna , glioma , oncogene , cancer research , carcinogenesis , protein kinase b , signal transduction , pi3k/akt/mtor pathway , suppressor , gene , mapk/erk pathway , gene expression , microbiology and biotechnology , cell cycle , genetics
MicroRNAs (miRNAs) are single-stranded, 18- to 23-nt RNA molecules that function as regulators of gene expression. Previous studies have shown that microRNAs play important roles in human cancers, including gliomas. Here, we found that expression levels of miR-181b were decreased in gliomas, and we identified IGF-1R as a novel direct target of miR-181b. MiR-181b overexpression inhibited cell proliferation, migration, invasion, and tumorigenesis by targeting IGF-1R and its downstream signaling pathways, PI3K/AKT and MAPK/ERK1/2. Overexpression of IGF-1R rescued the inhibitory effects of miR-181b. In clinical specimens, IGF-1R was overexpressed, and its protein levels were inversely correlated with miR-181b expression. Taken together, our results indicate that miR-181b functions in gliomas to suppress growth by targeting the IGF-1R oncogene and that miR-181b may serve as a novel therapeutic target for gliomas.
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