Open AccessA structure-based model of RIG-I activation
Author(s) -
Daniel Kolakofsky,
Eva Kowalinski,
S. Cusack
Publication year - 2012
Publication title -
rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.037
H-Index - 171
eISSN - 1469-9001
pISSN - 1355-8382
DOI - 10.1261/rna.035949.112
Subject(s) - biology , rig i , innate immune system , computational biology , rna silencing , microbiology and biotechnology , receptor , rna , genetics , rna interference , gene
A series of high-resolution crystal structures of RIG-I and RIG-I:dsRNA cocrystals has recently been reported. Comparison of these structures provides considerable insight into how this innate immune pattern recognition receptor is activated upon detecting and binding a certain class of viral RNAs.
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