English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In this paper we study the changes and significance of the TXA 2  and PGI 2  metabolism after infrasonic damage to rats so as to probe the mechanism of infrasonic biological effects. Some 40 SD rats were randomized into control, infrasonic damage once, 7 times, 14 times, and treatment five groups. A stimulus of 8Hz 120dB infrasound was applied to the infrasonic damage groups for 2 hours once according to the planned times. Radioimmunoassay was used for the examination of brain TXB 2  and 6-keto-PGF1a (metabolites of TSA 2  and PGI 2 ) contents. The results showed that there were no changes in TXB 2  and 6-keto-PGF1a levels in the ‘once’ group while TXB 2  level elevated significantly and 6-keto-PGF1a level decreased remarkably in the 7 times and the 4 times groups with an augmentation of TXA 2 /PGI 2  value. In the treatment group both TXB 2  and PGI 2  levels nearly reached normal. It is concluded that the augmentation of the TXA 2 /PGI 2  value in the 7 times and 14 times groups suggests that an imbalance in TXA 2 -PGI 2  production contributes to the traumatic secondary processes, which include ischemia and edema. Also, the extent of TXA 2  and PGI 2  metabolism disturbance is closely related to the times of infrasonic injury. It is hypothesized that mGluR antagonist may exert its protective properties through increasing PGI 2  production in the injured brain by improving the blood supply to injured blood vessels.

The Changes and Significance of TXA2 and PGI2 Metabolism after Rat Infrasonic Brain Damage

The Changes and Significance of TXA₂ and PGI₂ Metabolism after Rat Infrasonic Brain Damage