Interference in the autoDELFIA® hAFP immunoassay and effect on second-trimester Down's syndrome screening | Zendy

Leanne Mannings | Zendy; Sandy Trow | Zendy; Janet Newman | Zendy; Barry Nix | Zendy; Carol Evans | Zendy

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Interference in the autoDELFIA^® hAFP immunoassay and effect on second-trimester Down's syndrome screening

Author(s) -

Leanne Mannings,

Sandy Trow,

Janet Newman,

Barry Nix,

Carol Evans

Publication year - 2011

Publication title -

annals of clinical biochemistry international journal of laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.6

H-Index - 80

eISSN - 1758-1001

pISSN - 0004-5632

DOI - 10.1258/acb.2011.011061

Subject(s) - immunoassay , second trimester , medicine , prenatal screening , chemistry , pregnancy , immunology , prenatal diagnosis , antibody , fetus , biology , genetics

Falsely decreased serum alphafetoprotein (AFP) concentrations are reported in the autoDELFIA(®) hAFP immunoassay due to interference by complement. AFP is measured, using this assay, as part of second-trimester and integrated Down's syndrome screening tests. Decreased AFP concentrations increase the calculated risk of Down's syndrome; therefore falsely low AFP, due to assay interference, may artificially increase a patient's risk, and have the potential to cause false screen positive results. It was our aim to assess whether negative interference in the autoDELFIA(®) hAFP assay was a cause of very low AFP concentrations, and to examine the effect of falsely decreased concentrations on the calculated risk of Down's syndrome.

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