Stress cardiomyopathy – a unique presentation of diabetic ketoacidosis | Zendy

Sudip Nanda | Zendy; Santo Longo | Zendy; Surya P. Bhatt | Zendy; John Pamula | Zendy; Shree Sharma | Zendy; Thompson H. Dale | Zendy

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Stress cardiomyopathy – a unique presentation of diabetic ketoacidosis

Author(s) -

Sudip Nanda,

Santo Longo,

Surya P. Bhatt,

John Pamula,

Shree Sharma,

Thompson H. Dale

Publication year - 2009

Publication title -

annals of clinical biochemistry international journal of laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.6

H-Index - 80

eISSN - 1758-1001

pISSN - 0004-5632

DOI - 10.1258/acb.2009.008237

Subject(s) - diabetic ketoacidosis , diabetic cardiomyopathy , cardiomyopathy , diabetes mellitus , medicine , ketoacidosis , endocrinology , oxidative stress , metabolism , type 1 diabetes , heart failure

We have documented a unique instance of diabetic ketoacidosis (DKA)-induced stress-related cardiomyopathy (CMP) in a 46-yr-old Caucasian female with type I diabetes mellitus. In times of stress, tissues with high capacity for aerobic metabolism, like myocardium, can preferentially change their metabolic substrate to ketones. The myocyte has a decreased ability to metabolize glucose and free fatty acids in stress CMP. To the best of our knowledge this is the first report of stress CMP complicating DKA. A possible mechanism for the same is hypothesized.

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