Simultaneous determination of guanidinoacetate, creatine and creatinine in urine and plasma by un-derivatized liquid chromatography-tandem mass spectrometry | Zendy

Rachel S Carling | Zendy; Sarah Hogg | Zendy; Timothy C. Wood | Zendy; J Calvin | Zendy

Open Access

Simultaneous determination of guanidinoacetate, creatine and creatinine in urine and plasma by un-derivatized liquid chromatography-tandem mass spectrometry

Author(s) -

Rachel S Carling,

Sarah Hogg,

Timothy C. Wood,

J Calvin

Publication year - 2008

Publication title -

annals of clinical biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.6

H-Index - 80

eISSN - 1758-1001

pISSN - 0004-5632

DOI - 10.1258/acb.2008.008029

Subject(s) - creatine , creatinine , chemistry , chromatography , urine , analyte , tandem mass spectrometry , mass spectrometry , liquid chromatography–mass spectrometry , detection limit , biochemistry

Creatine plays an important role in the storage and transmission of phosphate-bound energy. The cerebral creatine deficiency syndromes (CCDS) comprise three inherited defects in creatine biosynthesis and transport. They are characterized by mental retardation, speech and language delay and epilepsy. All three disorders cause low-creatine signal on brain magnetic resonance spectroscopy (MRS); however, MRS may not be readily available and even when it is, biochemical tests are required to determine the underlying disorder.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research