Open AccessIn vivo activity of orally administered antibiotics and chemotherapeutics against acute septicaemic pasteurellosis in rabbits
Author(s) -
L. Okerman,
Lot A. Devriese,
D. Gevaert,
Erik Uyttebroek,
Freddy Haesebrouck
Publication year - 1990
Publication title -
laboratory animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 63
eISSN - 1758-1117
pISSN - 0023-6772
DOI - 10.1258/002367790780865994
Subject(s) - pasteurellosis , antibiotics , in vivo , medicine , pharmacology , biology , microbiology and biotechnology , pasteurella multocida , bacteria , genetics
Different antibiotics and chemotherapeutics were tested for therapeutic efficacy in rabbits, in an experimental model using a Pasteurella multocida strain which causes hyperacute septicaemia in this animal species. Only enrof1oxacin, administered in the drinking water at a concentration of 50-100 mg/l cured the rabbits, provided that a daily intake of 5 mg/kg body weight was achieved. The other drugs tested (tetracycline, spiramycin, erythromycin and a combination of sulfamerazine with trimethoprim), at doses recommended for rabbits, showed little or no activity at all, with the exception of chloramphenicol, which was only partially effective.