Open AccessHistopathology of streptozotocin-induced diabetic DBA/2N and CD-1 mice
Author(s) -
Kazuhito Honjo,
Kunio Doi,
Chiyo Doi,
Tomotari Mitsuoka
Publication year - 1986
Publication title -
laboratory animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 63
eISSN - 1758-1117
pISSN - 0023-6772
DOI - 10.1258/002367786780808695
Subject(s) - streptozotocin , histopathology , pancreas , muscle hypertrophy , medicine , endocrinology , diabetes mellitus , hepatocyte , pathology , periodic acid–schiff stain , islet , biology , immunohistochemistry , biochemistry , in vitro
Histopathological examinations were carried out on female DBA/2N and CD-1 mice which were autopsied 4 and 12 weeks after six daily intraperitoneal injections of streptozotocin (SZ). Histopathological changes related to SZ treatment were found in the pancreas, liver and kidneys. Little difference was observed between the two strains in the histological changes of the pancreas (a decrease in size of the islets, and degranulation and a decrease in the number of B cells) and liver (hypertrophy of hepatocytes and cytoplasmic invagination into hepatocyte nuclei). With regard to the changes in the kidneys, DBA/2N mice showed characteristic inclusions positive to periodic acid-Schiff reagent in the distal tubule epithelial cells, while CD-1 mice showed remarkable luminal dilatation and epithelial cell deformation of distal tubules. SZ-induced diabetes had no innuence on the development of spontaneous cardiovascular lesions in DBA/2N mice under the present experimental conditions.