Humoral immune response to infection with Encephalitozoon cuniculi in rabbits | Zendy

T. Waller | Zendy; Brør Morein | Zendy; Eva Fabiansson | Zendy

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Humoral immune response to infection with Encephalitozoon cuniculi in rabbits

Author(s) -

T. Waller,

Brør Morein,

Eva Fabiansson

Publication year - 1978

Publication title -

laboratory animals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.62

H-Index - 63

eISSN - 1758-1117

pISSN - 0023-6772

DOI - 10.1258/002367778780936331

Subject(s) - encephalitozoon cuniculi , seroconversion , antibody , immune system , biology , virology , immunogenicity , immunology , microbiology and biotechnology , medicine , microsporidia , spore

Parenteral administration of Encephalitozoon cuniculi induced an antibody response within 7--11 days. Peroral administration was less effective since only 2 of 6 animals showed seroconversion; they became seropositive within 14--21 days. Sera from animals which became seropositive had high antibody titres during the whole test period. Immune sera from 3 animals were fractionated by gel filtration. With the india-ink immunoreaction test, antibodies to E. cuniculi were found only in the 7S fractions, while the indirect fluorescent-antibody test detected them in fractions 19S and 7S. The 7S fractions were identified as IgG and the 19S fractions as IgM. A program for eradication of encephalitozoonosis, based on these results, is discussed.

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