Open AccessTime-Dependent Effect of Glutamate on Long-Term Potentiation in the Suprachiasmatic Nucleus of Rats
Author(s) -
Yukiko Nisikawa,
Takao Saruta,
Shigenobu Shibata,
Soichi Watanabe
Publication year - 2002
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.90.201
Subject(s) - long term potentiation , glutamate receptor , suprachiasmatic nucleus , stimulation , neuroscience , nucleus , chemistry , circadian rhythm , medicine , endocrinology , biology , receptor
The effect of glutamate on optic nerve stimulation-evoked field potentials in rat suprachiasmatic nucleus (SCN) was examined in vitro. Glutamate application for 20 min induced long-term potentiation (LTP) of the field potentials in the SCN at nighttime, whereas that induced a weak LTP at daytime. On the other hand, application for 40 min induced LTP in the SCN during the daytime, whereas it induced a weak one at nighttime. These results indicate that the effect of glutamate is dependent on the application time and that the effect is influenced by the duration of glutamate exposure.