Time-Dependent Effect of Glutamate on Long-Term Potentiation in the Suprachiasmatic Nucleus of Rats | Zendy

Yukiko Nisikawa | Zendy; Takao Shimazoe | Zendy; Shigenobu Shibata | Zendy; Shigenori Watanabe | Zendy

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Time-Dependent Effect of Glutamate on Long-Term Potentiation in the Suprachiasmatic Nucleus of Rats

Author(s) -

Yukiko Nisikawa,

Takao Shimazoe,

Shigenobu Shibata,

Shigenori Watanabe

Publication year - 2002

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.90.201

Subject(s) - long term potentiation , glutamate receptor , suprachiasmatic nucleus , stimulation , neuroscience , nucleus , chemistry , circadian rhythm , medicine , endocrinology , biology , receptor

The effect of glutamate on optic nerve stimulation-evoked field potentials in rat suprachiasmatic nucleus (SCN) was examined in vitro. Glutamate application for 20 min induced long-term potentiation (LTP) of the field potentials in the SCN at nighttime, whereas that induced a weak LTP at daytime. On the other hand, application for 40 min induced LTP in the SCN during the daytime, whereas it induced a weak one at nighttime. These results indicate that the effect of glutamate is dependent on the application time and that the effect is influenced by the duration of glutamate exposure.

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