Open AccessBoth Metabotropic Glutamate I and II Receptors Mediate Augmentation of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats
Author(s) -
Takao Saruta,
Yukiko Doi,
Ikumi Arai,
Akiko Yoshimatsu,
Takako Fukumoto,
Soichi Watanabe
Publication year - 2002
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.89.85
Subject(s) - metabotropic glutamate receptor , methamphetamine , metabotropic glutamate receptor 5 , pharmacology , metabotropic glutamate receptor 1 , dopamine , antagonist , agonist , chemistry , metabotropic receptor , metabotropic glutamate receptor 7 , glutamate receptor , neuroscience , biology , receptor , biochemistry
The role of metabotropic glutamate receptor (mGluR) on dopamine overflow from the striatum was studied in methamphetamine (MAP)-sensitized rats. The increase of dopamine release by MAP was significantly inhibited by perfusion of a mGluR antagonist R,S-alpha-methyl-4-carboxyphenylglycine. The perfused mGluR agonist [S,3R-1-aminocyclopentane-1,3-dicarboxylic acid enhanced the dopamine level. The enhancement was significantly attenuated by co-perfusion of a mGluR group I antagonist (S)-4-carboxy-3-hydroxyphenylglycine or a mGluR group II antagonist R,S-a-methyl-4-tetrazolylphenylglycine. These suggest that both mGluR group I and II mediate augmentation of dopamine release in MAP-sensitized rats.