Both Metabotropic Glutamate I and II Receptors Mediate Augmentation of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats | Zendy

Takao Shimazoe | Zendy; Yukiko Doi | Zendy; Ikumi Arai | Zendy; Akiko Yoshimatsu | Zendy; Takako Fukumoto | Zendy; Shigenori Watanabe | Zendy

Open Access

Both Metabotropic Glutamate I and II Receptors Mediate Augmentation of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats

Author(s) -

Takao Shimazoe,

Yukiko Doi,

Ikumi Arai,

Akiko Yoshimatsu,

Takako Fukumoto,

Shigenori Watanabe

Publication year - 2002

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.89.85

Subject(s) - metabotropic glutamate receptor , methamphetamine , metabotropic glutamate receptor 5 , pharmacology , metabotropic glutamate receptor 1 , dopamine , antagonist , agonist , chemistry , metabotropic receptor , metabotropic glutamate receptor 7 , glutamate receptor , neuroscience , biology , receptor , biochemistry

The role of metabotropic glutamate receptor (mGluR) on dopamine overflow from the striatum was studied in methamphetamine (MAP)-sensitized rats. The increase of dopamine release by MAP was significantly inhibited by perfusion of a mGluR antagonist R,S-alpha-methyl-4-carboxyphenylglycine. The perfused mGluR agonist [S,3R-1-aminocyclopentane-1,3-dicarboxylic acid enhanced the dopamine level. The enhancement was significantly attenuated by co-perfusion of a mGluR group I antagonist (S)-4-carboxy-3-hydroxyphenylglycine or a mGluR group II antagonist R,S-a-methyl-4-tetrazolylphenylglycine. These suggest that both mGluR group I and II mediate augmentation of dopamine release in MAP-sensitized rats.

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