Open AccessFunctional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins
Author(s) -
Kazuhide Ayajiki,
Tomio Okamura,
Kumiko Noda,
Noboru Toda
Publication year - 2002
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.89.197
Subject(s) - hexamethonium , nitric oxide , nicotine , medicine , vein , stimulation , anesthesia , pulmonary artery , artery , anatomy , cardiology , chemistry , endocrinology
In dog pulmonary arterial and venous strips without endothelium under treatment with prazosin, nicotine induced relaxation that was abolished by N(G)-nitro-L-arginine, hexamethonium and methylene blue. L-Arginine antagonized the N(G)-nitro-L-arginine action. Neurogenic relaxations tended to be more evident in the vein. Nitric oxide (NO)-induced relaxations were greater in the veins than in the arteries. Concentrations of NO to induce the same magnitude of relaxation as that to nicotine were higher in the arteries. In conclusion, dog pulmonary arteries and veins are innervated by nitroxidergic (nitrergic) nerves, and NO is released by nerve stimulation with nicotine in a larger amount in the artery than the vein.