Open AccessInhibitory Effect of Olopatadine Hydrochloride on the Sneezing Response Induced by Intranasal Capsaicin Challenge in Guinea Pigs
Author(s) -
Toshihiko Kaise,
Yukino Akamatsu,
Kenji Ohmori,
Akio Ishii,
Akira Karasawa
Publication year - 2001
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.86.258
Subject(s) - pharmacology , capsaicin , medicine , (+) naloxone , nasal administration , morphine , anesthesia , opioid , receptor
To investigate the possible inhibitory effect of olopatadine hydrochloride (olopatadine), an antiallergic drug, on the tachykinin-mediated nasal responses, we examined the effect of olopatadine on the sneezing and the nasal rubbing responses induced by intranasal capsaicin challenge in guinea pigs. Olopatadine (10 mg/kg, p.o.) inhibited the sneezing response by 57% without affecting the nasal rubbing one. The antihistamines chlorpheniramine and clemastine did not affect the responses. Morphine caused the inhibition of both responses, which was antagonized by naloxone. These results suggest that olopatadine inhibits the sneezing response by the inhibition of the tachykinin release and not by its antihistaminic action.