Open AccessInhibition of Concanavalin A-Induced Mice Hepatitis by Coumarin Derivatives
Author(s) -
Tosihihiro Okamoto,
Shigeaki Yoshida,
Tadashi Kobayashi,
Susumu Okabe
Publication year - 2001
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.85.95
Subject(s) - glycyrrhizin , imperatorin , coumarin , concanavalin a , chemistry , pharmacology , inhibitory postsynaptic potential , hepatitis , stereochemistry , biochemistry , endocrinology , medicine , chromatography , in vitro , organic chemistry , high performance liquid chromatography
The effects of coumarin derivatives, osthole, imperatorin, Pd-Ia, Pd-II and Pd-III, on mice concanavalin A (Con A) (0.2 mg/mouse, i.v.)-induced hepatitis were studied. At the dose of 200 mg/kg (i.p.), these coumarins inhibited more than 90% of the Con A-induced elevation of plasma alanine aminotransferase activity, but glycyrrhizin (200 mg/kg, i.p.) caused only 45% inhibition. At the dose of 100 mg/kg (i.p.), osthole produced the strongest inhibition among these coumarins. The inhibitory activity of osthole is lost when its 7-methoxy group is replaced by a 7-hydroxy group to form osthenol. The present results showed that coumarin derivatives inhibited Con A-induced hepatitis, with osthole being the most inhibitory.