Open AccessAntinociceptive Effect of Vitamin K2 (Menatetrenone) in Diabetic Mice
Author(s) -
Kenji Onodera,
Ko Zushida,
Junzo Kamei
Publication year - 2001
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.85.335
Subject(s) - vitamin k2 , medicine , nociception , vitamin , osteoporosis , intraperitoneal injection , diabetic neuropathy , endocrinology , diabetes mellitus , anesthesia , receptor
The antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice was examined using a tail-pressure test. Intraperitoneal injection of menatetrenone (10-100 mg/kg) produced a dose-dependent increase in the nociceptive threshold in diabetic mice. There was no significant difference between non-diabetic and diabetic mice in the menatetrenone-induced changes in the nociceptive threshold. The results suggest the therapeutical usefulness of menatetrenone for treating painful diabetic neuropathy and osteoporosis.