Open AccessEffect of Prolonged Nitric Oxide Synthesis Inhibition on Plasma Fibrinogen Concentration in Rats
Author(s) -
Kohichi Sugimoto,
Shuichi Tsuruoka,
Akio Fujimura
Publication year - 2001
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.85.114
Subject(s) - fibrinogen , candesartan , medicine , nitric oxide , endocrinology , arginine , chemistry , angiotensin ii , plasma concentration , receptor , biochemistry , amino acid
We examined whether nitro-L-arginine-methyl ester (L-NAME) causes a sustained elevation in plasma fibrinogen concentration in rats. Oral dosing of L-NAME (100 mg/kg per day) for 7 days significantly raised plasma fibrinogen concentration in rats. The increase in plasma fibrinogen, however, returned to control levels by the treatment for more than 7 days, in spite of progressive hypertension. Candesartan failed to reverse the transient hyperfibrinogenemia, indicating that the rise in plasma fibrinogen may occur through the mechanisms other than angiotensin II receptor activation. These data suggest that a prolonged L-NAME treatment does not cause chronic hyperfibrinogenemia in rats.