Open AccessEffect of Intracerebroventricular Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Scopolamine-Induced Amnesic Mice
Author(s) -
Satoru Suzuki,
Akito Kataoka,
Masayoshi Furushiro
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.84.86
Subject(s) - phosphatidylserine , phosphatidylcholine , pharmacology , chemistry , lecithin , medicine , chromatography , biochemistry , phospholipid , membrane
The effect of intracerebroventricularly administered soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) on memory impairment was evaluated by a passive avoidance task. SB-tPS significantly prolonged the step-through latency induced by scopolamine treatment as in our previous report where SB-tPS was orally administered. The same doses of soybean phosphatidylcholine were ineffective. This result indicates that SB-tPS can act on the brain without any peripheral modification.