Effect of Intracerebroventricular Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Scopolamine-Induced Amnesic Mice | Zendy

Satoru Suzuki | Zendy; Akito Kataoka | Zendy; Masayoshi Furushiro | Zendy

Open Access

Effect of Intracerebroventricular Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Scopolamine-Induced Amnesic Mice

Author(s) -

Satoru Suzuki,

Akito Kataoka,

Masayoshi Furushiro

Publication year - 2000

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.84.86

Subject(s) - phosphatidylserine , phosphatidylcholine , pharmacology , chemistry , lecithin , medicine , chromatography , biochemistry , phospholipid , membrane

The effect of intracerebroventricularly administered soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) on memory impairment was evaluated by a passive avoidance task. SB-tPS significantly prolonged the step-through latency induced by scopolamine treatment as in our previous report where SB-tPS was orally administered. The same doses of soybean phosphatidylcholine were ineffective. This result indicates that SB-tPS can act on the brain without any peripheral modification.

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