Ca2+-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle | Zendy

Ryo Yoshimoto | Zendy; Masatoshi Hori | Zendy; Katsuhito Takahashi | Zendy; S. Taniguchi | Zendy; Motoya Katsuki | Zendy; Hiroshi Ozaki | Zendy; Hideaki Karaki | Zendy

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Ca2+-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle

Author(s) -

Ryo Yoshimoto,

Masatoshi Hori,

Katsuhito Takahashi,

S. Taniguchi,

Motoya Katsuki,

Hiroshi Ozaki,

Hideaki Karaki

Publication year - 2000

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.84.474

Subject(s) - calponin , contraction (grammar) , sensitization , smooth muscle , muscle contraction , chemistry , biophysics , microbiology and biotechnology , medicine , endocrinology , neuroscience , biology

Role of h1 calponin on Ca2+-sensitivity of smooth muscle contraction was investigated using h1 calponin gene-deficient mice (CP -/-) and wild type mice (CP +/+). PGF2. induced a comparable force in intact aorta of CP +/+ and CP -/-. DPB showed similar effects to PGF2alpha. In membrane-permeabilized ileal smooth muscle, PDBu enhanced Ca2+-sensitivity of contraction comparably in CP +/+ and CP -/-. GTPgamma-S showed similar effects. Our results suggest that h1 calponin does not regulate Ca2+-sensitivity in the contractile mechanism of smooth muscle.

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