Open AccessXanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats
Author(s) -
Nobuaki Matsui,
Ikuko Satsuki,
Yuka Morita,
Keiichi Inaizumi,
Kazumi Kasajima,
Reiko Kanoh,
Nobuyuki Fukuishi,
Masaaki Akagi
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.84.363
Subject(s) - xanthine oxidase , allopurinol , reactive oxygen species , chemistry , thiobarbituric acid , ischemia , biochemistry , oxygen , xanthine , pharmacology , kappa , medicine , oxidative stress , enzyme , lipid peroxidation , organic chemistry , linguistics , philosophy
The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa B was activated in the liver of rats. The activation of NF-kappa B was inhibited by pretreatment of allopurinol (10-100 mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa B during ischemia.