Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats | Zendy

Nobuaki Matsui | Zendy; Ikuko Satsuki | Zendy; Yuka Morita | Zendy; Keiichi Inaizumi | Zendy; Kazumi Kasajima | Zendy; Reiko Kanoh | Zendy; Nobuyuki Fukuishi | Zendy; Masaaki Akagi | Zendy

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Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats

Author(s) -

Nobuaki Matsui,

Ikuko Satsuki,

Yuka Morita,

Keiichi Inaizumi,

Kazumi Kasajima,

Reiko Kanoh,

Nobuyuki Fukuishi,

Masaaki Akagi

Publication year - 2000

Publication title -

the japanese journal of pharmacology

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.84.363

Subject(s) - xanthine oxidase , allopurinol , reactive oxygen species , chemistry , thiobarbituric acid , ischemia , biochemistry , oxygen , xanthine , pharmacology , kappa , medicine , oxidative stress , enzyme , lipid peroxidation , organic chemistry , linguistics , philosophy

The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa B was activated in the liver of rats. The activation of NF-kappa B was inhibited by pretreatment of allopurinol (10-100 mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa B during ischemia.

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