Open AccessCorrection of Hyperglycemia and Insulin Sensitivity by T-1095, an Inhibitor of Renal Na+-Glucose Cotransporters, in Streptozotocin-Induced Diabetic Rats
Author(s) -
Akira Oku,
Kiichiro Ueta,
Keiichi Akita,
Tomomi Kano-Ishihara,
Takeshi Matsumoto,
Tomohiko Adachi,
Koichiro Yasuda,
Kinsuke Tsuda,
Katsuo Ikezawa,
Akira Saito
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.84.351
Subject(s) - medicine , endocrinology , streptozotocin , insulin resistance , diabetes mellitus , insulin , cotransporter , glucose transporter , chemistry , sodium , organic chemistry
We investigated the effects of T-1095 (3-(benzo[b]furan-5-yl)-2',6'-dihydroxy-4'-methylpropiophenone 2'-O-(6-O-methoxycarbonyl)-beta-D-glucopyranoside), an orally active inhibitor of Na+-glucose cotransporter, on hyperglycemia and insulin resistance in skeletal muscle of streptozotocin (STZ)-induced diabetic rats. Chronic (4 weeks) administration of T-1095 as food admixture (0.01 -0.1% wt/wt) suppressed the blood glucose level without affecting the food intake and body weight. In addition, the reduced 2-deoxyglucose uptake and lactate release in the soleus muscle of STZ rat was ameliorated by chronic treatment of T-1095. These data suggest that T-1095 improves insulin sensitivity in skeletal muscle through correction of hyperglycemia and has novel therapeutic potential for treatment of diabetes mellitus through removing glucose toxicity.