Open AccessCa2+-Independent Phospholipase A2 Inhibiror Impairs Spatial Memory of Mice.
Author(s) -
Shin-ichi Fujita,
Yuji Ikegaya,
Nobuyoshi Nishiyama,
Norio Matsuki
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.83.277
Subject(s) - hippocampal formation , spontaneous alternation , phospholipase a2 , blockade , phospholipase , hippocampus , neuroscience , chemistry , biology , endocrinology , medicine , biochemistry , enzyme , receptor
Pharmacological blockade of Ca2+-independent phospholipase A2 (PLA2) is reported to disintegrate hippocampal synaptic plasticity, which is thought to be the cellular mechanism underlying learning and memory. Therefore, we investigated the effect of the Ca2+-independent PLA2 inhibitor bromoenol lactone (BEL) on spontaneous alteration behaviors of mice. When 3 nmol BEL was intracerebroventricularly injected 30 min prior to the test, the mice showed a poor alternation ratio, compared with control animals. The data suggest that Ca2+-independent PLA2 activity is required for spatial memory.