Open AccessEffect of Zaldaride Maleate, an Antidiarrheal Compound, on 16,16-Dimethyl Prostaglandin E2-Induced Intestinal Ion Secretion in Rats.
Author(s) -
Nobuo Aikawa,
Akira Karasawa,
Kenji Ohmori
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.83.269
Subject(s) - forskolin , prostaglandin e2 , secretion , adenylate kinase , chemistry , endocrinology , medicine , calmodulin , small intestine , prostaglandin , vasoactive intestinal peptide , biology , receptor , enzyme , biochemistry , neuropeptide
The effect of zaldaride, a calmodulin inhibitor, on 16,16-dimethyl prostaglandin E2 (dmPGE2)-induced intestinal ion secretion was investigated in rats. Zaldaride inhibited the dmPGE2-induced increase in water content in the colon, but not that in the small intestine. In the colonic mucosa, zaldaride attenuated the dmPGE2-induced short-circuit current; however, it did not affect the forskolin or dibutyryl cAMP-induced effect. These results suggest that zaldaride inhibits dmPGE2-induced intestinal ion secretion by reducing the activity of Ca2+/calmodulin-dependent adenylate cyclase linked to a receptor, and the colon may be an important site in the action of zaldaride.