Effect of Zaldaride Maleate, an Antidiarrheal Compound, on 16,16-Dimethyl Prostaglandin E2-Induced Intestinal Ion Secretion in Rats. | Zendy

Nobuo Aikawa | Zendy; Akira Karasawa | Zendy; Kenji Ohmori | Zendy

Open Access

Effect of Zaldaride Maleate, an Antidiarrheal Compound, on 16,16-Dimethyl Prostaglandin E2-Induced Intestinal Ion Secretion in Rats.

Author(s) -

Nobuo Aikawa,

Akira Karasawa,

Kenji Ohmori

Publication year - 2000

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.83.269

Subject(s) - prostaglandin e2 , forskolin , secretion , chemistry , adenylate kinase , endocrinology , medicine , calmodulin , vasoactive intestinal peptide , cyclase , prostaglandin , receptor , biology , enzyme , biochemistry , neuropeptide

The effect of zaldaride, a calmodulin inhibitor, on 16,16-dimethyl prostaglandin E2 (dmPGE2)-induced intestinal ion secretion was investigated in rats. Zaldaride inhibited the dmPGE2-induced increase in water content in the colon, but not that in the small intestine. In the colonic mucosa, zaldaride attenuated the dmPGE2-induced short-circuit current; however, it did not affect the forskolin or dibutyryl cAMP-induced effect. These results suggest that zaldaride inhibits dmPGE2-induced intestinal ion secretion by reducing the activity of Ca2+/calmodulin-dependent adenylate cyclase linked to a receptor, and the colon may be an important site in the action of zaldaride.

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