Open AccessChanges in Seizure Susceptibility to Local Anesthetics by Repeated Administration of Cocaine and Nomifensine but Not GBR12935. Possible Involvement of Noradrenergic System.
Author(s) -
Tomoyuki Sato,
Shigeo Kitayama,
Kenichi Morita,
Teruaki Ikeda,
Toshihiro Dohi
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.83.265
Subject(s) - nomifensine , convulsion , pentylenetetrazol , anesthesia , lidocaine , procaine , medicine , pharmacology , dopamine , epilepsy , anticonvulsant , dopaminergic , psychiatry
We examined cross-sensitization of cocaine and synthetic local anesthetics to their seizure susceptibility after repeated administration. Seizure susceptibility of procaine and lidocaine increased after the end of two days of treatment with a subconvulsive dose of cocaine. Acute treatment with nomifensine but not GBR12935, a specific inhibitor of the dopamine transporter, facilitated lidocaine-induced convulsion. Furthermore, daily treatment with nomifensine for two days enhanced lidocaine-induced convulsion. These results suggest the possible involvement of the brain noradrenergic system in the changes in seizure susceptibility after repeated administration of some local anesthetics.