Changes in Seizure Susceptibility to Local Anesthetics by Repeated Administration of Cocaine and Nomifensine but Not GBR12935. Possible Involvement of Noradrenergic System. | Zendy

Tomoyuki Sato | Zendy; Shigeo Kitayama | Zendy; Katsuya Morita | Zendy; Tetsurou Ikeda | Zendy; Toshihiro Dohi | Zendy

Open Access

Changes in Seizure Susceptibility to Local Anesthetics by Repeated Administration of Cocaine and Nomifensine but Not GBR12935. Possible Involvement of Noradrenergic System.

Author(s) -

Tomoyuki Sato,

Shigeo Kitayama,

Katsuya Morita,

Tetsurou Ikeda,

Toshihiro Dohi

Publication year - 2000

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.83.265

Subject(s) - nomifensine , convulsion , pentylenetetrazol , anesthesia , lidocaine , procaine , medicine , pharmacology , dopamine , epilepsy , anticonvulsant , dopaminergic , psychiatry

We examined cross-sensitization of cocaine and synthetic local anesthetics to their seizure susceptibility after repeated administration. Seizure susceptibility of procaine and lidocaine increased after the end of two days of treatment with a subconvulsive dose of cocaine. Acute treatment with nomifensine but not GBR12935, a specific inhibitor of the dopamine transporter, facilitated lidocaine-induced convulsion. Furthermore, daily treatment with nomifensine for two days enhanced lidocaine-induced convulsion. These results suggest the possible involvement of the brain noradrenergic system in the changes in seizure susceptibility after repeated administration of some local anesthetics.

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