2-Bromoethylamine, a Suicide Inhibitor of Tissue-Bound Semicarbazide-Sensitive Amine Oxidase. | Zendy

Hiroyasu Kinemuchi | Zendy; Masato Jinbo | Zendy; Atsushi Tabata | Zendy; Yoshie Toyoshima | Zendy; Yuichiro Arai | Zendy; Takeshi Tadano | Zendy; Kensuke Kisara | Zendy; Lars Oreland | Zendy

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2-Bromoethylamine, a Suicide Inhibitor of Tissue-Bound Semicarbazide-Sensitive Amine Oxidase.

Author(s) -

Hiroyasu Kinemuchi,

Masato Jinbo,

Atsushi Tabata,

Yoshie Toyoshima,

Yuichiro Arai,

Takeshi Tadano,

Kensuke Kisara,

Lars Oreland

Publication year - 2000

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.83.164

Subject(s) - amine oxidase , semicarbazide , amine oxidase (copper containing) , chemistry , enzyme , amine gas treating , adduct , biochemistry , covalent bond , organic chemistry , diamine oxidase

Various mammalian tissues contain plasma membrane-bound amine oxidase, termed semicarbazide-sensitive amine oxidase (SSAO). In the present study, 2-bromoethylamine has been studied with regard to inhibitory properties towards tissue-bound SSAO in rat lung. Without preincubation, 2-bromoethylamine was a competitive and reversible SSAO inhibitor with a Ki value of 2.5 microM. After preincubation, it time-dependently and non-competitively inhibited SSAO activity, probably by forming the covalently-bound enzyme-inhibitor adduct. The data presented suggest that 2-bromoethylamine may act as a suicide inhibitor of SSAO.

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