Open AccessPhenytoin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria
Author(s) -
Atsushi Takahashi,
Kenji Onodera,
Hisashi Satoh,
Hideaki Mayanagi
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.82.82
Subject(s) - calvaria , phenytoin , metabolite , resorption , bone resorption , in vivo , endocrinology , medicine , chemistry , in vitro , biology , biochemistry , epilepsy , microbiology and biotechnology , psychiatry
The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.