Phenytoin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria | Zendy

Atsushi Takahashi | Zendy; Kenji Chiodera | Zendy; Hisashi Shinoda | Zendy; Hideaki Mayanagi | Zendy

Open Access

Phenytoin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria

Author(s) -

Atsushi Takahashi,

Kenji Chiodera,

Hisashi Shinoda,

Hideaki Mayanagi

Publication year - 2000

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.82.82

Subject(s) - calvaria , phenytoin , metabolite , resorption , bone resorption , in vivo , endocrinology , medicine , chemistry , in vitro , biology , biochemistry , epilepsy , microbiology and biotechnology , psychiatry

The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.

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