Open AccessProspects for Gene-Based Immunopharmacology in Salivary Glands
Author(s) -
Seiichi Yamano,
Bruce J. Baum
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.82.281
Subject(s) - immunopharmacology , gene transfer , genetic enhancement , gene , salivary gland , tumor immunology , immunology , biology , computational biology , medicine , pathology , genetics , immune system , immunotherapy
The clinical potential of gene transfer is increasing. One likely major application of this emerging biotechnology will be for gene therapeutics, the use of a gene as a drug. Salivary glands provide an unusual but increasingly valuable target site for gene transfer. Studies in animal salivary glands from several laboratories, including our own, have provided proof of this concept. In this review, we provide a background and perspective on possible strategies for gene-based immunopharmacology in salivary glands. We use as a target disease model the autoimmune exocrinopathy Sjögren's syndrome.