Open AccessEffects of Nitric Oxide Scavenger, Carboxy-PTIO on Endotoxin-Induced Alterations in Systemic Hemodynamics in Rats
Author(s) -
Katsuyuki Miura,
Shinya Yamanaka,
Tsuneyuki Ebara,
Michiaki Okumura,
Masahito Imanishi,
Shokei Kim,
Tatsuya Nakatani,
Hiroshi Itoh
Publication year - 2000
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.82.261
Subject(s) - nitric oxide , hematocrit , vascular resistance , cardiac output , shock (circulatory) , hemodynamics , lipopolysaccharide , scavenger , blood pressure , medicine , mean circulatory filling pressure , mean arterial pressure , systemic administration , free radical scavenger , septic shock , pharmacology , anesthesia , heart rate , chemistry , antioxidant , sepsis , biology , oxidative stress , central venous pressure , biochemistry , microbiology and biotechnology , in vivo
The present experiments were conducted to clarify the mode of cardiovascular action of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), a nitric oxide (NO) scavenger, during rat endotoxic shock by determining cardiac output and systemic arterial tone simultaneously. Lipopolysaccharide (LPS) (10 mg/kg, i.v.) decreased systemic blood pressure and cardiac output with transient increases in hematocrit and total vascular resistance. Administration of carboxy-PTIO (1.7 mg x kg(-1) x min(-1), i.v. for 60 min) at 90 min after LPS attenuated further decline in blood pressure and cardiac output without affecting changes in hematocrit or total vascular resistance. It is concluded that carboxy-PTIO attenuates endotoxin-induced hypotension predominantly by maintaining cardiac output in rat experimental endotoxic shock.