Open AccessEffects of .BETA.-Blockers and Nicardipine on Oxotremorine-Induced Tremor in Common Marmosets.
Author(s) -
Minoru Mitsuda,
Masahiro Nomoto,
S. Iwata
Publication year - 1999
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.81.244
Subject(s) - oxotremorine , nicardipine , propranolol , medicine , channel blocker , essential tremor , beta (programming language) , intensity (physics) , pharmacology , anesthesia , chemistry , physical medicine and rehabilitation , physics , receptor , blood pressure , muscarinic acetylcholine receptor , quantum mechanics , computer science , programming language , calcium
Effects of beta-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. Generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. Intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. The total intensity of oxotremorine-induced tremor for each drug was expressed as "points", which were the sum of tremor intensity scores evaluated every 10 min up to 190 min following the administration of oxotremorine. Beta-blockers significantly suppressed the tremor. On the other hand, the Ca2+ channel blocker exacerbated the tremor.