Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig. | Zendy

Yukio Hara | Zendy; Akihito Chugun | Zendy; Keisuke Futamura | Zendy; Takeshi Nishino | Zendy; Hiroshi Kondo | Zendy

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Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig.

Author(s) -

Yukio Hara,

Akihito Chugun,

Keisuke Futamura,

Takeshi Nishino,

Hiroshi Kondo

Publication year - 1999

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.81.122

Subject(s) - diazepam , guinea pig , calcium , cardiac muscle , new guinea , medicine , anesthesia , pharmacology , chemistry , ethnology , history

Influences of diazepam, a benzodiazepine derivative, on the contractile response to calcium in skinned trabecular fibers of guinea pig heart were examined. Diazepam (100 microM) enhanced the contractile response of the skinned fiber to calcium and shifted the concentration-response curve to the left. The pCa50 values were 6.07+/-0.03 and 6.28+/-0.03 (P<0.05) in the absence and presence of diazepam, respectively. This result suggests that diazepam increases calcium sensitivity of contractile proteins in heart muscles.

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