Effects of a Lipoxygenase Inhibitor, Panaxynol, on Vascular Contraction Induced by Angiotensin II | Zendy

Shinji Takai | Zendy; Denan Jin | Zendy; Kirimura Kazuyoshi | Zendy; Junko Ikeda | Zendy; Sakaguchi Masato | Zendy; Baba K | Zendy; Tadashi Fujita | Zendy; Miyazaki Mizuo | Zendy

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Effects of a Lipoxygenase Inhibitor, Panaxynol, on Vascular Contraction Induced by Angiotensin II

Author(s) -

Shinji Takai,

Denan Jin,

Kirimura Kazuyoshi,

Junko Ikeda,

Sakaguchi Masato,

Baba K,

Tadashi Fujita,

Miyazaki Mizuo

Publication year - 1999

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.80.89

Subject(s) - chemistry , contraction (grammar) , angiotensin ii , lipoxygenase , renin–angiotensin system , medicine , endocrinology , aorta , blood pressure , hamster , biochemistry , enzyme

We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster. IC50 values in the intact and endothelial cell-denuded aorta were 23 and 20 microM, respectively. In SHR, the mean arterial pressure after injection of 30 and 60 mg/kg panaxynol was reduced, and the maximum hypotensive values were 23 and 48 mmHg, respectively. Thus, lipoxygenase products may affect the renin-angiotensin system.

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