Open AccessEffects of a Lipoxygenase Inhibitor, Panaxynol, on Vascular Contraction Induced by Angiotensin II
Author(s) -
Shinji Takai,
Denan Jin,
Kazuyoshi Kirimura,
Junko Ikeda,
Masato Sakaguchi,
Baba K,
Tadashi Fujita,
Mizuo Miyazaki
Publication year - 1999
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.80.89
Subject(s) - chemistry , contraction (grammar) , angiotensin ii , lipoxygenase , renin–angiotensin system , medicine , endocrinology , aorta , blood pressure , hamster , biochemistry , enzyme
We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster. IC50 values in the intact and endothelial cell-denuded aorta were 23 and 20 microM, respectively. In SHR, the mean arterial pressure after injection of 30 and 60 mg/kg panaxynol was reduced, and the maximum hypotensive values were 23 and 48 mmHg, respectively. Thus, lipoxygenase products may affect the renin-angiotensin system.