Open AccessPharmacological Evaluation of a New Laser Blood Flowmeter for Measuring Coronary Blood Flow, Assessed in the Canine Isolated, Blood-Perfused Ventricular Tissue Preparation in Comparison With an Electromagnetic Flowmeter
Author(s) -
Atsushi Sugiyama,
Shunji Takehana,
Keitaro Hashimoto
Publication year - 1999
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.80.263
Subject(s) - blood flow , flow measurement , medicine , biomedical engineering , laser , cardiology , physics , optics , thermodynamics
A new portable-type laser blood flowmeter was recently developed for measuring the blood flow in vessels. The sensitivity and specificity of the laser flowmeter was assessed in comparison with the well-established electromagnetic flowmeter using a canine isolated, blood-perfused ventricular tissue preparation. The laser flowmeter can record the phasic pattern of the coronary blood flow like the electromagnetic flowmeter. The extent of the changes after intracoronary administration of ACh and angiotensin II as well as coronary occlusion was almost identical between these two methods. These results suggest that the new laser flowmeter may possess potential utilities in both basic experimental and clinical practices.