Open AccessDietary Salt Loading Increases Nitric Oxide Synthesis in Transgenic Mice Overexpressing Sodium-Proton Exchanger
Author(s) -
Jun Ichi Kiraku,
Toshio Nakamura,
Takao Sugiyama,
Naoyuki Takahashi,
Makoto Kuroo,
Jun Fujii,
Ryozo Nagai
Publication year - 1999
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.80.181
Subject(s) - nitric oxide , sodium , chemistry , salt (chemistry) , genetically modified mouse , medicine , sodium nitrite , sodium–hydrogen antiporter , blood pressure , nitrite , endocrinology , transgene , sodium nitrate , excretion , nitrate , biochemistry , inorganic chemistry , biology , food science , organic chemistry , gene
We studied the role of nitric oxide (NO) synthesis in amelioration of blood pressure elevation during dietary salt loading in transgenic mice overexpressing sodium proton exchanger. Systolic blood pressure rose after starting salt loading only in the high-salt group of transgenic mice. However, this elevation of blood pressure was not continued. Urinary excretion of inorganic nitrite and nitrate in the high-salt group of transgenic mice was significantly higher than in the high-salt group of control mice. These results suggest that increased NO synthesis in response to salt loading is one of the anti-hypertensive mechanisms in transgenic mice overexpressing sodium proton exchanger.