Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats | Zendy

Nakamura Kazuki | Zendy; Yamaguchi Yu | Zendy; Kagota Satomi | Zendy; Kazumasa Shinozuka | Zendy; Kunitomo Masaru | Zendy

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Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats

Author(s) -

Nakamura Kazuki,

Yamaguchi Yu,

Kagota Satomi,

Kazumasa Shinozuka,

Kunitomo Masaru

Publication year - 1999

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.79.505

Subject(s) - cordyceps , kupffer cell , in vivo , clearance rate , colloid , chemistry , medicine , endocrinology , pharmacology , biology , food science , microbiology and biotechnology

We investigated the effect of water extracts of Cordyceps sinensis (WECS) on Kupffer cell function in rats. Rats were received a single i.v. injection of a colloidal carbon solution and then the clearance rate from the blood were measured. The rats had been daily administered with WECS, p.o. at a dose of 200 mg/kg for 25 days until the day before the injection of colloidal carbon. The half-life of the colloidal carbon in the blood of rats administered WECS 200 mg/kg was significantly shorter than that of the control rats. This suggests that accelerated function of Kupffer cells is partially involved in the anti-metastatic action of WECS.

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