Open AccessActivation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
Author(s) -
Kazuki Nakamura,
Yu Yamaguchi,
Satomi Kagota,
Kazumasa Shinozuka,
Masaru Kunitomo
Publication year - 1999
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.79.505
Subject(s) - cordyceps , kupffer cell , in vivo , clearance rate , colloid , chemistry , medicine , endocrinology , pharmacology , biology , food science , microbiology and biotechnology
We investigated the effect of water extracts of Cordyceps sinensis (WECS) on Kupffer cell function in rats. Rats were received a single i.v. injection of a colloidal carbon solution and then the clearance rate from the blood were measured. The rats had been daily administered with WECS, p.o. at a dose of 200 mg/kg for 25 days until the day before the injection of colloidal carbon. The half-life of the colloidal carbon in the blood of rats administered WECS 200 mg/kg was significantly shorter than that of the control rats. This suggests that accelerated function of Kupffer cells is partially involved in the anti-metastatic action of WECS.