Open AccessAbility of Mosapride to Bind to 5-HT4 Receptor in the Human Stomach
Author(s) -
Yasuko Sakurai-Yamashita,
Kohei Takada,
Keiko Takemura,
Kimihiro Yamashita,
Akihito Enjoji,
Takashi Kanematsu,
Kohtaro Taniyama
Publication year - 1999
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.79.493
Subject(s) - mosapride , myenteric plexus , stomach , receptor , guinea pig , 5 ht4 receptor , medicine , motility , endocrinology , biology , chemistry , serotonin , microbiology and biotechnology , immunohistochemistry
Ability of mosapride, a gastrokinetic agent, to bind to 5-HT4 receptor was examined in the stomach of human and guinea pig by in vitro receptor autoradiography. [125I]SB207710 binding sites were detected in the muscle layer including the myenteric plexus of the stomach from both humans and guinea pigs, although the binding was observed more clearly and densely in the stomach of guinea pigs than humans. Mosapride as well as SB204070 inhibited the binding of [125I]SB207710. Thus, mosapride possesses the ability to bind to 5-HT4 receptors of human stomach and may modulate the motility, as in the case of guinea pig stomach.