Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187-Induced Histamine Release From Rat Peritoneal Exudate Cells | Zendy

Okazaki Masako | Zendy; Mayumi Tsuji | Zendy; Yamazaki Yukako | Zendy; Kanda Yuko | Zendy; Iwai Shinichi | Zendy; Oguchi Katsuji | Zendy

Open Access

Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187-Induced Histamine Release From Rat Peritoneal Exudate Cells

Author(s) -

Okazaki Masako,

Mayumi Tsuji,

Yamazaki Yukako,

Kanda Yuko,

Iwai Shinichi,

Oguchi Katsuji

Publication year - 1999

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.79.489

Subject(s) - ionophore , histamine , calcium , extracellular , exudate , biology , endocrinology , inhibitory postsynaptic potential , degranulation , medicine , chemistry , biochemistry , botany , receptor

The effects of Sasa senanensis Rehder extract (SE) by alkaline hydrolysis on histamine release from rat peritoneal exudate cells (PECs) were examined. Preincubation with SE for 5 min suppressed calcium-ionophore A23187-induced histamine release in a concentration-dependent manner. A23187 evoked a quick increase in cytoplasmic free calcium ([Ca2+]i) levels in the presence of extracellular calcium. Preincubation with SE also had an inhibitory effect on calcium influx increases induced by A23187. These results indicate that SE prevents degranulation from rat PECs by inhibiting [Ca2+]i level elevation.

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