Open AccessMorphometric Evidence That YM175, a Bisphosphonate, Reduces Trabecular Bone Resorption in Ovariectomized Dogs With Dietary Calcium Restriction
Author(s) -
Naoto O’uchi,
H. Nishikawa,
Hiroyuki Motoie,
Hisataka Shikama
Publication year - 1999
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.79.397
Subject(s) - ovariectomized rat , bone resorption , cancellous bone , resorption , medicine , endocrinology , chemistry , calcium , osteoporosis , anatomy , estrogen
We examined mechanisms by which incadronate disodium (YM175) prevented bone resorption in ovariectomized dogs with dietary calcium restriction using the morphometrical method. YM175 (0.01-1.0 mg/kg) was given to ovariectomized dogs for 18 months. Because lumbar bone mineral density remained constant at month 17, we assumed that the trabecular bone resorption rate was equal to the bone formation rate and that wall thickness equaled resorption cavity depth. YM175 decreased both the bone resorption rate per number of osteoclasts and resorption cavity depth of cancellous pockets which were increased in ovariectomized dogs. These results suggest that YM175 reduces bone loss by decreasing the resorbing activity of osteoclasts.